SyllabusScope

Genomics and Proteomics

7. Genomics and Proteomics · Part-A: General Biotechnology

BIOINFORMATICS Bioinformatics

Databases, sequence analysis, alignment, phylogenetics and structure prediction as computational disciplines.

18 sub-topics

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01

Introduction to genomics (nuclear, mitochondrial and chloroplast genome structure

  • CELL.ORGANELLE
02

computational sequence analysis - finding genes and regulatory regions, gene annotation, similarity searches, pairwise and multiple alignments, alignment statistics

  • BIOINFORMATICS
03

prediction of gene function using homology, context, structures, networks

  • BIOINFORMATICS
06

genome-analysis tools - PCR, RFLP, DNA fingerprinting, RAPD, automated sequencing

  • GENOMICS_OMICS
10

genome sequencing (Human Genome Project landmarks, BAC and shotgun libraries, cytogenetic, contig and restriction maps, sequencing and assembly, model organisms and other genome projects, comparative genomics of pathogens and non-pathogens, evolution of a pathogen, 16S rRNA typing and sequencing)

  • GENOMICS_OMICS
11

DNA microarray technology (cDNA and oligonucleotide arrays, global gene-expression analysis, comparative transcriptomics, differential expression, genotyping and SNP detection, detection technology, computational analysis)

  • GENOMICS_OMICS
12

proteomics (typical proteomics experiment, 2D analysis, spot visualization and picking, tryptic digestion and peptide fingerprinting, mass spectrometry - ion sources MALDI and spray, analyzers ToF, quadrupole and ion trap, detectors

  • METHODS.SPECTROSCOPY
16

protein-protein interactions - solid-phase ELISA, pulldown assays, far-western, SPR, yeast two-hybrid, phage display

  • BIOMOL.STRUCTURE