SyllabusScope

Bioinformatics and Computational Biology

B4. Bioinformatics and Computational Biology · Part-B: Specialized Branches

BIOINFORMATICS Bioinformatics

Databases, sequence analysis, alignment, phylogenetics and structure prediction as computational disciplines.

18 sub-topics

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05

pattern-sequence resources InterPro, Prosite, Pfam, ProDom, Gene Ontology)

  • BIOINFORMATICS
07

sequence analysis (similarity versus identity, homologues, orthologues and paralogues, tandem and interspersed repeats, repeat finding)

  • BIOINFORMATICS
12

structural biology (3-D visualization and simulation, molecular modelling, computer representations of molecules, external and internal coordinates, molecular mechanics, force fields)

  • DRUG_DESIGN
13

proteins (secondary structure elucidation, peptide bond, phi, psi and chi torsion angles, Ramachandran map, hierarchical organization - CATH, SCOP, FSSP)

  • BIOMOL.STRUCTURE
15

classification and comparison of protein 3D structures (secondary-structure prediction - Chou-Fasman, GOR

  • BIOMOL.STRUCTURE
16

tertiary-structure prediction, homology and comparative modelling, fold recognition, threading, ab initio methods, CASP

  • BIOINFORMATICS
18

applications in drug design (NCI and PubChem, receptor-ligand interactions, structure-based design, binding-site identification and virtual screening, ligand-based design, SAR, QSAR and pharmacophores, in-silico prediction of drug activity and ADMET)

  • DRUG_DESIGN