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Pharmaceutical Biotechnology

B10. Pharmaceutical Biotechnology · Part-B: Specialized Branches

MEDICAL_BIOTECH Biotechnology

Diagnostics, vaccines, cell and gene therapy, antibody engineering and biosensors for clinical use.

6 sub-topics

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01

Drug metabolism (biotransformation, microsomal and non-microsomal mechanisms, enzymes in transformation, enzyme inhibition and induction, factors affecting drug metabolism, metabolism in fetus and newborn, dose-effect relationship, adverse drug reactions and interactions, toxic and allergic reactions, idiosyncrasy, acute poisoning and treatment, extraction of drug from plasma and tissues)

  • MEDICAL_BIOTECH
02

pharmacological screening and assays (screening principles and correlation between animal models and human situations, animal ethics, screening models for hypertension, cerebral ischemia, pain, epilepsy, depression, Parkinson's, Alzheimer's and diabetes

  • STATISTICS
03

in-vitro versus in-vivo screens, cell-based, biochemical and radiological assays, high-throughput screening, pharmacokinetic analysis

  • MEDICAL_BIOTECH
04

animal handling, routes of administration, dose-response relationships, analgesic activity determination, protein and haematological parameter estimation)

  • BIOMOL.STRUCTURE
05

enzymes and microbial technology (enzymes in organic solvents and ionic liquids, biocatalysts, enzyme engineering, random and rational protein engineering, biocatalysis with lipase, amidase, aminopeptidase, acylase, hydantoinase, lyases, oxidoreductase, nitrilase, epoxide hydrolase, hydroxylase, aldolases and decarboxylases

  • ENZYME_TECH
06

immobilization of enzymes and whole cells, design, operation and kinetics of immobilized enzyme reactors, diffusional resistance and Thiele modulus, multi-step immobilized enzyme systems)

  • ENZYME_TECH